Agustin, Tri Andini (2026) Pabrik Asam Asetilsalisilat (Aspirin) (C9H8O4) dari Asam Salisilat (C7H6O3) dan Asetat Anhidrat (C4H6O3) dengan Proses Sintesis Kalsium Oksida (CaO). Undergraduate thesis, UPN Veteran Jawa Timur.
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Abstract
Acetylsalicylic acid or aspirin is one of the chemical compounds widely used in the pharmaceutical industry as an active ingredient for analgesic, antipyretic, anti-inflammatory, and antiplatelet drugs. The increasing demand for aspirin in the health sector has led to a continuous rise in product demand year by year. However, the demand for aspirin in Indonesia is still largely met through imports, therefore the establishment of an aspirin plant domestically presents a promising opportunity. Therefore, it is planned to establish an acetylsalicylic acid (aspirin) plant using salicylic acid and acetic anhydride through a synthesis process with calcium oxide. The plant is scheduled to begin operation in 2030 with a production capacity of 50,000 tons/year and will be located in the Citangkil Industrial Area, Cilegon City, Banten Province. The plant will operate continuously for 330 days per year with a total workforce of 148 employees. Aspirin production is carried out through the reaction of salicylic acid, acetic anhydride, and calcium oxide in a Continuous Stirred Tank Reactor (CSTR). Prior to entering the reactor, all raw materials are prepared and fed with a molar ratio of 2 : 2 : 1 according to process requirements. Calcium oxide is used to bind the acetic acid formed during the reaction, thereby optimizing aspirin formation. Before entering the reactor, each raw material is preheated to 85°C and then directed to the reactor according to process requirements. The reaction takes place at 85°C, 1 atm, with a residence time of approximately 48 minutes. The reaction is exothermic; therefore, the reactor is equipped with a cooling system to maintain the temperature. The reaction product is then sent to an evaporator for evaporation and subsequently to a crystallizer for aspirin crystallization. The slurry from the crystallizer is fed to a centrifuge to separate the solid from the mother liquor. The aspirin cake is then dried using a rotary dryer, cooled, size-reduced using a ball mill, and stored in a silo prior to packaging. The final product obtained is aspirin with a purity of approximately 95%.
| Item Type: | Thesis (Undergraduate) | ||||||||
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| Subjects: | T Technology > TP Chemical technology > TP155 Chemical engineering | ||||||||
| Divisions: | Faculty of Engineering > Departement of Chemical Engineering | ||||||||
| Depositing User: | tri andini agustin | ||||||||
| Date Deposited: | 31 Aug 2026 03:11 | ||||||||
| Last Modified: | 31 Aug 2026 03:11 | ||||||||
| URI: | https://repository.upnjatim.ac.id/id/eprint/59159 |
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