Salsabila, Naurahyani Syifa (2025) Prediksi dan Pemetaan Potensi Peptida Bioaktif dari Udang Fermentasi Tradisional (Terasi) dan Analisa Potensi Bioaktivitas Penghambat Diabetes Menggunakan Pendekatan Bioinformatika. Undergraduate thesis, UPN Veteran Jawa Timur.
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Abstract
Bioactive peptide compounds in shrimp and its derivative products are currently a research focus due to their rich protein content. However, these food products require further processing because their high protein content makes them highly perishable to microbes. One such further processing method is fermentation, which can extend product shelf life, increase market value, and enhance nutritional value by producing bioactive peptides beneficial for health. Several peptide compounds successfully isolated and identified from shrimp paste have been found to possess biological activities such as antioxidant, anti-aging, ACE inhibitor, antibacterial, anti-diabetic, and antidepressant properties. This research aims to predict, identify, and further map the potential of bioactive peptides from shrimp paste responsible for diabetes inhibitory activity or as DPP-IV inhibitors using a bioinformatics (in silico) approach with a protein-peptide based molecular docking method. Peptide fragment modeling was performed using the PEP-FOLD 3 server, and the best conformations were selected for molecular docking against the Dipeptidyl peptidase IV (DPP-IV) receptor macromolecule using AutoDock Vina application and the Gaussian-based Neural Network for Interaction Affinity (GNINA) web-server. The interaction results from molecular docking were visualized with Discovery Studio Visualizer 2024. Based on the results of protein-peptide based molecular docking, the bioactive peptide compounds from shrimp paste, according to AutoDock Vina, namely VPPHL (-8.8 kcal/mol), HVVLPPLY (-8.6 kcal/mol), PHAIL (-8.1 kcal/mol), and according to GNINA, namely HVVLPPLY (-9.53 kcal/mol), VPPHL (-9.4 kcal/mol), PHAIL (-8.3 kcal/mol) were able to bind well to the active site of the DPP-IV receptor and show potential as DPP-IV inhibitors in anti-diabetic therapy.
| Item Type: | Thesis (Undergraduate) | ||||||||||||
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| Subjects: | T Technology > TP Chemical technology > TP368 Food processing and manufacture | ||||||||||||
| Divisions: | Faculty of Engineering > Departement of Food Engineering | ||||||||||||
| Depositing User: | Naurahyani Syifa Salsabila | ||||||||||||
| Date Deposited: | 20 Jun 2025 01:59 | ||||||||||||
| Last Modified: | 20 Jun 2025 01:59 | ||||||||||||
| URI: | https://repository.upnjatim.ac.id/id/eprint/38279 |
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