Hypocholesterolemic Effect of Pedada (Sonneratia caseolaris) Fruit Flour in Wistar Rats

Jariyah, Jariyah and Azkiyah, Lailatul and Widjanarko, Simon Bambang and Estiasih, Teti and Yuwono, Sudarminto S and Yunianta, Yunianta (2013) Hypocholesterolemic Effect of Pedada (Sonneratia caseolaris) Fruit Flour in Wistar Rats. International Journal of PharmTech Research, 5 (4). pp. 1619-1627. ISSN 0974-4304

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Pedada fruit is rich in dietary fiber and phenolic compounds which can reduce cholesterol levels in humans. The aim of this study was to investigate the cholesterol-lowering effect of pedada fruit flour (PFF) in rats. Five normal male Wistar rats were the normal control group (0) were fed AIN-93 M and twenty hypercholesterolemia male Wistar rats were randomly divided into 4 groups with different diets for 4 weeks. Group 1 (the hypercholesterolemia control) was fed an AIN-93M diet, no supplements. Groups 2, 3 and 4 were fed AIN-93M supplemented with 3%, 6%, and 9% PFF, respectively. Blood samples were taken on week 0, 1 st , nd rd 2 , 3 th , and 4 for total plasma cholesterol, high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and triglyceride analyses. The results showed that the PFF supplement significantly decreased (P = 0.000) the total plasma cholesterol levels by 32.45 -58.87 mg/dl; LDL-c by 32.06 - 55.54 mg/dl (p =0.000); triglyceride by 9.20 - 23.93 mg/dl (P = 0.000) respectively. HDL-c concentration remained unaltered (P = 0.997). These results indicate the beneficial effect of PFF in the treatment of hypercholesterolemia. This effect is possible related to dietary fiber and phenol compounds on PFF. Keywords: Pedada fruit flour (PFF), Hypercholesterolemia, Total cholesterol, LDL-c, HDL-c, Triglyceride, Rat.

Item Type: Article
Subjects: T Technology > TP Chemical technology > TP368 Food processing and manufacture
Depositing User: Fatchullah Fatchullah
Date Deposited: 18 Jan 2021 05:44
Last Modified: 18 Jan 2021 05:44
URI: http://repository.upnjatim.ac.id/id/eprint/1305

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