Hypoglycemic effect of Pedada (Sonneratia caseolaris) Fruit Flour (PFF) in alloxan-induced diabetic rats

Jariyah, Jariyah and Widjanarko, Simon Bambang and Yunianta, Yunianta and Estiasih, Teti (2014) Hypoglycemic effect of Pedada (Sonneratia caseolaris) Fruit Flour (PFF) in alloxan-induced diabetic rats. International Journal of PharmTech Research, 7 (1). pp. 31-40. ISSN 0974-4304

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Our study provided evidence for the hypoglycemic effect of dietary fiber from Pedada Fruit Flour (PFF) in alloxan-induced diabetic rats. PFF is formulated to feed standard AIN-93M as a replacement of Carboxyl Methyl Cellulase (CMC) diet composition. Meal Tolerance Test (MTT) consisted of three groups with six rats each, i.e 3%, 6% and 9% PFF. Blood glucose levels were monitored for 120 min after feeding intervals 30 minutes. The hypoglycemic effects of PFF in alloxan diabetic rats were studied for 4 weeks. The diabetic rats were divided into 5 groups and each was administrated with the same treatment in MTT with compared group of fed: glibenclamide, hyperglycemic and one group of normal rats as control. Blood glucose and body weight levels was weekly monitored. At the end of feeding treatment we determined the Short Chain Fatty Acids (SCFAs) profile from caecum digesta. The MTT showed that all concentration of PFF affected the absorption of glucose in the blood and the lowest blood glucose improvement was 23.89%, indicated the highest ability on glucose absorption. The hypoglycemic effect of PFF was significantly reducing glucose blood in diabetic rats (P<0.05), i.e. 31.29%. In the other hand, the effect of PFF increase body weight in diabetic rats (P<0.05) with magnitude of 5.25% (glibenclamide), 0.85% (3% PFF), 0.49% (6% PFF), and 4.19% (9% PFF). The concentration of all SCFAs profile is similar, i.e acetic acid > propionic acid > butyric acid. Keywords: Hypoglycemic; Meal Tolerance Test (MTT); Pedada Fruit Flour (PFF); SCFA.

Item Type: Article
Subjects: T Technology > TP Chemical technology > TP368 Food processing and manufacture
Depositing User: Fatchullah Fatchullah
Date Deposited: 18 Jan 2021 05:21
Last Modified: 18 Jan 2021 05:45
URI: http://repository.upnjatim.ac.id/id/eprint/1304

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